SCI 260 SU Biochemistry Doubl

Lesson 7

Read pages 1-5 of the case study, “Statins Stat!” (see attached pdf below), and answer the following questions.

1. Why are high density lipoproteins (HDLs) considered the “good cholesterol”? In your answer explain specifically what HDLs do that cause it to be considered the “good cholesterol”.

2. Why are low density lipoproteins (LDLs) considered the “bad cholesterol”? In your answer explain specifically what LDLs do that cause it to be considered the “bad cholesterol”.

3. What is the role of the phospholipid monolayer at the outer surface of lipoprotein particles? (Question 1 of case study)

4. Why are cholesterol, cholesteryl esters, and triglycerides preferentially contained inside lipoprotein particles? (Question 2 of case study)

5. What are the two sources of cholesterol in the human body?

6. What is a “committed step” in a biochemical pathway? (Question 3 of case study)

7. Looking at Figure 4 of case study (the reaction pathway from acetyl-CoA), which enzyme is likely to be the target of the statin mevastatin? (Question 6 of case study)

8. What are four (4) ways that HDL levels can be increased in the body?

9. What type of inhibitor (non-competitive OR competitive) are statins with respect to HMG-CoA reductase enzyme activity? Explain why.

10. How were cholesterol-lowering statin drugs first discovered?

You will earn 10 pts for correctly answering each question (total points earned is 100). You may use the Internet and/or your textbook to assist you, but please DO NOT copy your answers directly from the Internet or textbook.

Lesson 8

SCI260 – Introduction to Biochemistry Lesson #9 (1) Which of the double-stranded DNA sequences below will require more heat to separate the two strands (select Option A or Option B)? (2) Why is more heat is required to separate the strands? Option A 5’-GGACTCCCGGGTGAG-3’ 3’-CCTGAGGGCCCACTC-5’ Option B 5’-AACTGTTTAAAGACA-3’ 3’-TTGACAAATTTCTGT-5’ (3) What will be the mRNA sequence that is produced during the transcription of the DNA sequence below? Hint: As we discussed in class, there is a slight difference in the nucleotides used in DNA vs RNA. 5’-ACGTCAGGTTTCCGT-3’ (4) Based on what was discussed in Lecture 9, name four (4) enzymes/proteins that play a role in human DNA replication, and briefly describe the specific role each plays during human DNA replication. You may use the internet and/or your textbook to assist you. Each answer is worth 25 points (be sure to answer ALL four questions) giving you a maximum total of 100 points for this assignment. Please DO NOT copy your answers directly from the textbook or the internet.

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