Please respond to the following 2 post with references. 2 each part

Can you help me understand this Writing question?

#Part 1: 135 words response

The dysfunction of any these components can hinder the ability of the heart to pump actively and effectively and can in, in turn, reduce the amount of work produced, they can also increase the demand of oxygen by the heart to produce the same amount of work, for example, a chronic increase in heart blood pressure will increase the amount of force exerted by the left ventricle of the heart, which will start to hypertrophy as a result of the increased workload, this left ventricle hypertrophy could, in turn, lead to dilated cardiomyopathy affecting the contractility of the left ventricle, this can be followed by the NT-proBNP, a molecule produced by the ventricles that is useful in patients with heart failure (Oliveros et al., 2019). The increased blood pressure can cause elevated lung arterial pressures affecting the preload, and the damage to the endothelium of arteries and their thickening can increase the TPR or afterload, in conjunction the cardiovascular systems undergo a feedback loop that makes high blood pressure and its complications hard to manage.

Part #2 135 words response

Where to begin with this case study? I will focus on the woman’s weight/obesity. With her BMI at 32, she is defined as having obesity. Obesity is currently recognized as a major global epidemic. 70.7% of the American adult population are deemed overweight or obese. Studies have shown that obesity predisposes to hypertension and CVD. A 2-kg (4.4lb) loss in weight would result in a decline of 3.7mmHg in systolic and a 2.7 mmHg in diastolic blood pressure. In addition, structural changes in the kidneys secondary to obesity are significant. Pressure of peri-renal fat, coupled with increased abdominal pressure secondary to central obesity, contributes to altered renal sodium reabsorption. Also, emerging evidence shows that visceral adipose tissue, relative to subcutaneous adipose tissue, is more sensitive to lipolysis and secretes higher amounts of inflammatory cytokines, playing a large role in the CVD spectrum as well. (Wahab et al, 2020). For her height, she should weigh between 104 and 131 lbs (Dept of HHS, 2013). Immediate and strict diet restrictions should be educated to this woman to decrease her weight. Referral to registered dietician would be a suggestion as well. An exercise program should be started as tolerated as well. Increased monitoring of her blood pressure would be addressed as well. Continued and frequent follow-up visits would be scheduled to evaluate.

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